Expression (Wang et al., 2005). Other studies in muscle have demonstrated that the nature of the transgene can affect the development of an immune response. Membrane-bound -gal delivered via AAV was found to be more immunogenic than cytoplasmic transgene, presumably because it was more accessible for uptake by DCs and presentation to T cells on MHC class I and II (Sarukhan et al., 2001). Hopefully


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