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Ed in 2010 [63]. Working with a construct of 2-AR that contained a more native ICL3 sequence, Zhang et al. were able to determine HDX MScompatible conditions that allowed the dynamics of the receptor in complex with the inverse agonist carazolol to be profiled [63]. It was observed that all the transmembrane helices were resistant to exchange; however, the ICL regions were highly dynamic. Although
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Ed in 2010 [63]. Working with a construct of 2-AR that contained a more native ICL3 sequence, Zhang et al. were able to determine HDX MScompatible conditions that allowed the dynamics of the receptor in complex with the inverse agonist carazolol to be profiled [63]. It was observed that all the transmembrane helices were resistant to exchange; however, the ICL regions were highly dynamic. Although
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